A summary of: Isolation, Selection and Characteristics of Lactobacillus paracasei subsp. paracasei F19
Jump to study detailsF19 demonstrated key probiotic traits, including fiber degradation, antioxidant production, and immunomodulatory activity, indicating its strong potential for beneficial effects in the large intestine.
Method and selection
The study uses both in vivo and in vitro methods.
Design:
Treatment: Lactobacillus strains were isolated from the deep colonic mucus layer of patients without gastrointestinal disease and screened for binding of porcine mucin. At autopsy, the colon was rinsed and biopsies were taken.
Where and when: Stockholm
Sample size: 74 patients.
Sample criteria: Patients admitted for a non-gastrointestinal disease were selected, provided they had not been treated with antibiotics during 3 months prior to sampling.
Results and indicative results
Lactobacillus F19 and the other selected strains display characters that should enable them to survive passage to the large intestine in that they tolerate the acidic environment in the stomach (s. 5.).
The presented data show that Lactobacillus F19 has a documented ability to survive during passage in the GI tract and exerts multiple determinants for colonization and establishment, also expressed during conditions resembling those in the gut. Properties like fiber degradation, immunomodulatory effect and production of antioxidants make Lactobacillus F19 a strain, which is likely to exert further beneficial effects in the large intestine. (s. 6).